Buy Apalutamide 60mg (Apnat) Tablet online at Lowest Price

Apalutamide  (Apnat) is a nonsteroidal antiandrogen (NSAA) used to treat advanced prostate cancer, including forms that resist treatment despite low testosterone levels. It works by blocking androgen receptors, which are proteins that prostate cancer cells need to grow. This stops cancer cells from receiving signals that help them multiply and survive, slowing or stopping the disease.

Mechanism Of Action

Apalutamide attaches to androgen receptors and blocks testosterone and similar hormones from activating them. When these hormones activate the receptor, it moves into the cell’s nucleus and switches on genes that make the cancer grow. By preventing this, Apalutamide stops the cancer cells from dividing and spreading.

In advanced prostate cancer, the disease can adapt to survive even when testosterone is very low. Tumor cells increase the number of androgen receptors or change them so they respond more strongly to the small amounts of hormone still in the body. Apalutamide is effective against these changes, preventing the receptors from working no matter how many are present or how they are altered.

Unlike older drugs like Bicalutamide, which sometimes unintentionally activates the receptor, Apalutamide only blocks it. This makes the treatment more reliable and reduces the chance of cancer cells escaping control. Apalutamide also works consistently throughout the body, keeping the receptors shut down.

Apalutamide (Apnat) Usage 

Apalutamide (Apnat) is used for two types of prostate cancer:

• Non-Metastatic Castration-Resistant Prostate Cancer (nmCRPC): This type of prostate cancer hasn't spread yet but keeps growing even with very low testosterone levels. Apalutamide is used alongside androgen deprivation therapy (ADT) to delay the spread of cancer. Studies show it significantly increases the time before metastasis, extending metastasis-free survival by over 2 years.

• Metastatic Castration-Sensitive Prostate Cancer (mCSPC): In this stage, cancer has spread but still responds to testosterone suppression. When used with ADT, Apalutamide improves survival and slows disease progression. 

• Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): In this form, cancer has spread beyond the prostate but is still responsive to testosterone suppression. Apalutamide, used with ADT, helps to slow cancer growth and improve survival. The TITAN trial showed that this combination increases overall survival and delays progression, especially for those with bone or visceral metastases.

Apalutamide (Apnat) Dosage

With Apalutamide, you'll take four 60 mg tablets to reach the daily dose of 240 mg. You can take these tablets with or without food but aim to take them at the same time each day for the best results.

This medication works alongside treatment to lower testosterone, which can happen through surgery or medication. Your doctor will guide you on the right approach.

Everyone's body reacts differently to medicine. If side effects become too intense, your doctor might adjust your dose or briefly stop treatment. You'll also need regular check-ups to keep an eye on your blood pressure and liver health.

Apalutamide (Apnat) Side Effects

Apalutamide (Apnat) can cause side effects, although most are manageable.

Common Side Effects

If you experience any of these side effects, talk to your doctor, especially if they’re severe or don’t improve:

• Weakness and Tiredness: Apalutamide reduces testosterone, which can leave you feeling unusually drained or fatigued. This is common and may improve with rest and light activity.

• Joint Pain: Hormonal changes caused by the medication can lead to joint discomfort. Over-the-counter pain medications or gentle movement exercises like yoga can often relieve these aches.

• Muscle Weakness or Stiffness: The reduction in testosterone can also make muscles feel weaker or tighter than usual. Stretching and staying active might ease these symptoms.

• Diarrhea: Apalutamide can upset your digestion, causing loose stools. Drink plenty of water and let your doctor know if it doesn’t settle with basic treatments.

• Nausea and Loss of Appetite: All the symptoms can make eating difficult and lead to weight loss. Try smaller meals and snacks to maintain your energy.

• Weight Loss: Hormonal changes may lead to unintended weight loss, mostly due to muscle loss or reduced appetite. Your doctor might recommend supplements or diets.

• Hot Flashes: A sudden feeling of warmth, sweating, or flushing is common due to how Apalutamide affects body temperature control. It’s not dangerous and can often be managed with lifestyle changes.

• Swelling in Limbs: Some people notice swelling in their hands, feet, arms, or legs, likely from fluid buildup. Elevating the swollen areas and avoiding salty foods can help.

Serious Side Effects

• Seizures: Apalutamide can occasionally affect brain activity and lead to seizures, especially if you’ve had seizures or neurological conditions in the past.

• Fainting or Falls: Feeling faint or losing balance can happen due to fatigue, dizziness, or weakened muscles. Take care to move slowly, especially when getting up, and avoid situations where falling might cause injury.

• Broken Bones: Apalutamide can weaken bones over time, making fractures more likely. Let your doctor know if you suspect a fracture or have unusual pain in your bones.

• Heart or Lung Problems: Symptoms like chest pain, trouble breathing, or swelling in your feet or ankles could mean your heart or lungs are under stress. These need immediate attention.

• Stroke Symptoms: Watch for sudden numbness or weakness (especially on one side of your body), trouble speaking or understanding, blurry vision, or problems with balance. These are signs of a potential stroke and require emergency care.

• Severe Skin Reactions: Rashes (which already appeared in 25% of patients in a study), blisters, peeling skin, or flu-like symptoms can signal a serious reaction to the medication. Get medical help right away if these appear.

• Breathing Problems: If you develop a cough, fever, or feel extremely tired, it could indicate an infection or lung inflammation. Let your doctor know immediately.

Apalutamide Price & Buy Online

Apalutamide’s price in USA—around $2,800 to $3,000 monthly—comes from years of research and clinical trials like SPARTAN and TITAN. These studies were used to prove how the drug could slow cancer progression and give patients more time. Aplutamide price in Uk is almost same as USA.

It goes up higher in other countries. For instance, Apalutamide price Malaysia can go up as high as RM 13,500 and Apalutamide price in Philippines is higher than 185,000 PHP.

Indian generic manufacturers can produce Apalutamide under the brand name Apnat at a much lower cost because they don't have to invest in the initial research and clinical trials. With lower costs for labor and bigger production runs, they create the same medicine at a much lower price.

You can buy Apalutamide online from us with the lowest prices, helping patients get the treatment they need without the financial toll. Please contact us via Email or WhatsApp to get the best Apalutamide price quotation.
 

Apalutamide Safety Advice

Alcohol

No major interactions with alcohol, but it might increase side effects like dizziness or fatigue. It's best to drink in moderation.

Pregnancy

Apalutamide is contraindicated in pregnancy. Men should use contraception with partners who could get pregnant during treatment and for 3 months after.

Breastfeeding

Apalutamide is not for use by women, including those breastfeeding. Its effects on infants are unknown, so caution is advised.

Driving

Since Apalutamide can cause dizziness or tiredness, it's important to see how it affects you before driving or operating machinery.

Liver

If you have liver issues, use Apalutamide carefully. Your doctor may need to adjust the dose and monitor your liver function regularly.

Doctor Advice

Always talk to your doctor before starting Apalutamide, especially if you're on other medications or have health conditions. Make sure to share all your medical info.