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Dasatinib (Dasanat) is an oral medication used to treat chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is a second-generation tyrosine kinase inhibitor (TKI). This means it blocks certain proteins that help cancer cells grow.

The main target of Dasatinib is the BCR-ABL fusion protein. This protein causes uncontrolled cell division in CML. By inhibiting BCR-ABL, Dasatinib disrupts the signaling pathways that drive cancer cell growth and survival.

Dasatinib also targets other kinases, particularly those in the SRC family. These kinases are involved in cancer progression and metastasis. By affecting multiple pathways, Dasatinib can work well for patients whose cancers are resistant to first-generation TKIs like Imatinib.

Additionally, Dasatinib penetrates tissues well. This makes it useful for treating leukemia that has spread to the central nervous system.

Dasatinib Usage 

Dasatinib (Dasanat) is primarily used for:

• Chronic Myeloid Leukemia (CML): Dasatinib effectively treats all phases of CML: chronic, accelerated, and blast. It targets the BCR-ABL fusion protein, which drives the proliferation of cancer cells. 

• Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL): Dasatinib serves as a first-line treatment or for relapsed Ph+ ALL. It inhibits the BCR-ABL protein, improving patient outcomes. A doctor might do regular monitoring to help adjust doses based on response.

• Acute Myeloid Leukemia (AML): In specific subtypes of AML associated with the Philadelphia chromosome, Dasatinib can be beneficial. It may be part of combination therapies to enhance treatment effectiveness.

• Systemic Mastocytosis: Dasatinib treats systemic mastocytosis, a disorder with excessive mast cell accumulation. It controls symptoms and reduces mast cell proliferation.

• Non-Small Cell Lung Cancer (NSCLC): Dasatinib may be used for NSCLC patients with BCR-ABL mutations. It effectively targets these cancer cells.

Dasatinib Dosage

For chronic-phase CML, the usual dose is 100 mg once daily. In more advanced stages or Ph+ ALL, the dose is often 140 mg once daily. Your doctor may change the dose based on how well your body responds. Dasatinib should be taken with water at the same time each day, and the tablets should not be crushed or chewed. It is available in 50mg & 20mg strength.

Dasatinib Side Effects

Dasatinib (Dasanat) may cause several side effects, some common and others more serious. Common side effects include:

• Low Blood Counts: Dasatinib can lower your white blood cells, red blood cells, and platelets. This happens because it affects the bone marrow. You may feel tired and be more prone to infections. You might also notice easy bruising since your body isn't making enough healthy cells.

• Fluid Retention: Dasatinib may cause fluid retention. This can happen because it affects blood vessel function and how the kidneys work. You may notice swelling in your face, arms, legs, or abdomen. In some cases, extra fluid can build up in the lungs, leading to shortness of breath.

• Digestive Issues: Nausea, vomiting, and diarrhea can occur while taking Dasatinib. The drug may irritate the lining of your stomach and intestines. While these symptoms are usually mild, you might also experience constipation or a loss of appetite.

• Skin Reactions: Skin rashes, itching, and dryness are common with Dasatinib. The drug can affect how skin cells grow and retain moisture. Although these reactions are often mild, they can reduce your comfort.

• Muscle and Joint Pain: Dasatinib can lead to muscle aches and joint pain. This may be due to inflammation and how the drug interacts with the muscles and joints. If these symptoms become severe or last a long time, let your doctor know.

• Pulmonary Arterial Hypertension (PAH): In rare cases, Dasatinib may cause high blood pressure in the lungs. This is due to its effect on blood vessels. PAH can lead to serious breathing problems, as your heart has to work harder to pump blood through narrowed arteries.

When taking Dasatinib, be aware of interactions that might affect your treatment. Alcohol use, pregnancy, breastfeeding, driving, and liver health can all influence safety and effectiveness. Below is a breakdown of all its common interactions.

Dasatinib Price & Availability

Dasatinib price is expensive because of its complicated production process. Making the drug involves detailed methods, like multi-step chemical reactions, to create its specific structure. This structure is necessary for its function as a tyrosine kinase inhibitor. Before dasatinib can be sold, it must also go through strict clinical trials. 

These trials include Phase I, II, and III studies that test its safety and effectiveness against chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Each trial phase adds to the overall cost.

Furthermore, purifying dasatinib requires advanced techniques, such as chromatography. This process ensures the drug is pure enough for safety, but it also increases production costs. A lot of research is also needed to understand how dasatinib works. Scientists study the best dosages and the long-term effects. All these factors make dasatinib very costly.

In addition, local factors like import fees and distribution issues can raise the Dasatinib price in the Philippines, USA & other countries. At Medixo, you can find high-quality generic Dasatinib under the brand name Dasanat at the best price. Our generics meet strict quality standards, making effective treatment more accessible for you. Please contact us via WhatsApp or send an E-mail to get best discounted price & buy dasatinib online from us.

Dasatinib Safety Advice

Alcohol

Avoid alcohol as it may worsen side effects such as dizziness or nausea.

Pregnancy

Dasatinib can harm the fetus. Women should use contraception during treatment and for six months afterward.

Breastfeeding

Do not breastfeed while on Dasatinib, as it may pass into breast milk and harm the baby.

Driving

Dasatinib may cause dizziness or fatigue. Make sure you feel alert before driving or operating machinery.

Liver

Patients with liver issues need regular liver tests to monitor for potential damage, as Dasatinib can increase liver enzymes.

Doctor Advice

Keep up with regular check-ups and report any new symptoms immediately. Your doctor may adjust dosages to manage side effects effectively.