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Docetaxel (Daxotel) is a chemotherapy drug used to treat several types of cancer, such as breast, lung, prostate, stomach, and head and neck cancers. It’s part of a group of medicines called taxanes, which work by stopping cancer cells from dividing and growing. 

As for its mechanism of action, Docetaxel attacks rapidly growing cells, specifically by disrupting the structures inside cells that help them multiply. This helps slow down or stop the cancer, reducing the size of tumors and preventing the disease from spreading further. This medication is administered via an IV drip, allowing gradual entry into the bloodstream. 
Treatments are usually done at a hospital or clinic, and each session lasts about an hour. It’s often given in cycles, which means there are rest periods between treatments to allow your body to recover.

Docetaxel Usage 

Docetaxel (Daxotel) is prescribed for specific types of cancer, with dosage tailored to each patient's needs. Here’s an overview of its use for different cancers.

• Breast Cancer: Docetaxel is used for advanced breast cancer or cases where cancer has spread (metastasized). By targeting cancer cells, it helps reduce tumor size, slow down progression, and can be combined with other treatments.

• Lung Cancer: In patients with non-small cell lung cancer (NSCLC), Docetaxel helps shrink tumors and ease symptoms, especially when the cancer cannot be handled with surgery or has spread to other parts of the body.

• Prostate Cancer: For men with advanced prostate cancer, particularly when other treatments have stopped working, Docetaxel helps slow the cancer's spread and relieve pain. It is used with prednisone to manage symptoms more effectively.

• Stomach Cancer: Docetaxel is used for advanced stomach cancer, helping to reduce tumors and improve swallowing and digestion problems related to the disease.

• Head and Neck Cancer: For cancers affecting areas such as the mouth, throat, or sinuses, Docetaxel helps slow tumor growth and improve symptoms like pain or difficulty swallowing.

Dosage

The dose of Docetaxel is based on factors like your body size (measured in BSA), the type of cancer, and your overall health. Typically, it’s given every 3 weeks with an IV infusion. To help reduce the risk of side effects, you may be given steroids (such as dexamethasone) before your treatment starts.

Docetaxel Side Effects 

Like most chemotherapy drugs, docetaxel (Daxotel) has side effects due to its impact on rapidly dividing cells, affecting both cancerous and healthy cells in hair, skin, and blood. Here’s a summary of the most common side effects and their causes:

• Allergic Reaction: Docetaxel can cause allergic reactions, with symptoms like itchy skin, rashes, dizziness, swelling, or breathing difficulties. Joint or muscle pain may also occur. Dexamethasone is prescribed to lower this risk; take it as directed. Notify your nurse of any symptoms during treatment or contact your doctor later.

• Injection Site Pain: Docetaxel may cause burning or stinging if it leaks under the skin during infusion, along with soreness at the injection site. Inform your nurse immediately if you feel burning. After treatment, applying a cool compress or soaking the area in cool water for 15–20 minutes can relieve discomfort.

• Hair Loss: Hair loss is a common side effect of docetaxel. Some patients may experience persistent alopecia, especially those on higher doses. This results from damage to hair follicles. Scalp cooling techniques may help reduce hair loss during treatment.

• Fluid Retention: Fluid retention may occur with docetaxel, leading to swelling in the feet, hands, or abdomen, as well as shortness of breath or rapid weight gain. Dexamethasone can help manage this. Elevate your feet and avoid tight clothing. Report any swelling or breathing issues to your doctor.

• Nausea and Vomiting: Nausea may occur with docetaxel, and uncontrolled vomiting can lead to dehydration. Your doctor may prescribe anti-nausea medication. Follow instructions closely, drink fluids, and eat smaller meals. Contact your doctor if nausea or vomiting continues.

• Peripheral Neuropathy: Peripheral neuropathy can occur with docetaxel, causing numbness, tingling, or pain in the hands and feet due to nerve damage. Symptoms may improve after treatment, but some individuals may experience lasting effects.

• Nail Changes: Nail changes, such as discoloration, brittleness, or ridging, can occur with docetaxel. Onycholysis, where the nail separates from the nail bed, may also happen. Most changes usually reverse after treatment.

Each person’s response to chemotherapy is different. While these side effects are common, not everyone will experience all of them, and they can vary in intensity. Your healthcare team will work closely with you to manage any side effects that arise.

Docetaxel Price & Availability

Docetaxel is expensive because it’s made using a complex process. It starts with using needles from yew trees. Turning these natural ingredients into a safe cancer treatment requires advanced technology and strict quality checks. This increases the overall cost. The drug also needs special storage and transport to stay effective. The Docetaxel price in the Philippines is particularly high due to differences in the healthcare system and import costs. Likewise, the Docetaxel price in Malaysia can also be steep for similar reasons.

However, generic versions may help make it more affordable in most cases. We focus on providing Indian Generic Docetaxel at the lowest rates possible, so patients in these regions can start the treatments they need easily. Please send your enquiry with us now to get the best price of docetaxel.

Docetaxel Safety Advice

Alcohol

Keep alcohol consumption at a minimum. Docetaxel itself contains ethanol, which can lead to symptoms of alcohol intoxication during and after administration. The FDA warns that patients may experience dizziness, confusion, or drowsiness. Any patient must avoid any tasks that need focus for at least one to two hours post-infusion to prevent accidents.

Pregnancy

Docetaxel is contraindicated during pregnancy due to its potential to cause severe harm to the developing fetus, including birth defects. Women of childbearing age are advised to use effective contraception during treatment and for two months afterward. Male patients should also ensure effective birth control for four months post-treatment.

Breastfeeding

There is no available data on the presence of docetaxel in human milk, nor on its effects on milk production or breastfed infants. Due to serious risks, including toxic effects, hepatotoxicity, and neutropenia, women should avoid breastfeeding during treatment and for two weeks after the final dose.

Driving

Due to the alcohol content in docetaxel, patients are advised against driving or operating machinery for one to two hours after infusion. The drug may impair cognitive function and motor skills, increasing the risk of accidents. Monitoring for symptoms of intoxication is essential during this period.

Liver

Patients with liver problems should be careful when taking docetaxel, as the alcohol can worsen liver issues. The FDA recommends using formulations with less alcohol for these patients and keeping a close eye on liver function during treatment to prevent any harmful effects.

Doctor Advice

If you are receiving docetaxel for prostate cancer, check your blood counts regularly. The drug can lower your white blood cell levels, increasing your infection risk. Report any signs of infection, such as fever or a sore throat. Following your prescribed corticosteroids, like dexamethasone, helps reduce side effects. Stay hydrated to prevent issues like tumor lysis syndrome; drink plenty of fluids before and after your infusion. This treatment is best managed under your doctor's supervision.