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Nintedanib (Nindanib) is a medication that works as a tyrosine kinase inhibitor. It is made up of a small molecule designed to block certain proteins called receptor tyrosine kinases. These proteins send signals inside cells that are important for cell growth and survival. When activated, they can cause uncontrolled cell division and the formation of new blood vessels, a process known as angiogenesis. By blocking these proteins, Nintedanib disrupts the signals that help tumors grow and spread. This slows down or stops the progression of diseases characterized by excessive cell growth.

Nintedanib specifically targets several types of receptors, including vascular endothelial growth factor (VEGF) receptors, fibroblast growth factor (FGF) receptors, and platelet-derived growth factor (PDGF) receptors. By doing so, it reduces the supply of nutrients and oxygen to tumors, which are necessary for their growth.

The medication is taken by mouth and absorbed in the gastrointestinal tract. It enters the bloodstream, allowing it to reach various tissues in the body. Some side effects can occur, as with many medications. Common side effects include gastrointestinal issues like diarrhea, nausea, and abdominal pain. These side effects can usually be managed with care.

Overall, Nintedanib is important in treating conditions linked to abnormal cell growth and blood vessel formation. Its targeted action helps control disease progression and improve patient outcomes.

Nintedanib Dosage

Most conditions will require the patient to take a dose of 100-150 mg twice daily. However, for NSCLC, the usual dose is 200 mg twice daily.

It is normally administered alone, though it may also be combined with Docetaxel for more effective second-line treatment of advanced NSCLC.

Nintedanib Usage 

Nintedanib (Nindanib) is primarily used for the treatment of the following conditions:

• Idiopathic Pulmonary Fibrosis (IPF): Nintedanib is approved for treating idiopathic pulmonary fibrosis, a lung disease that causes scarring of lung tissue. The scarring leads to reduced lung function over time, making it difficult to breathe. By inhibiting the receptor tyrosine kinases involved in fibrosis, Nintedanib helps slow the progression of lung scarring. This action can improve lung function and quality of life for patients, allowing them to maintain better oxygen levels and physical activity.

• Non-Small Cell Lung Cancer (NSCLC): Nintedanib is also used in combination with chemotherapy for patients with non-small cell lung cancer. This type of lung cancer represents a significant portion of lung cancer cases—about 80% of them. By blocking the growth signals provided by receptor tyrosine kinases, Nintedanib helps slow tumor growth and can enhance the effectiveness of chemotherapy. It targets both tumor cells and the blood vessels that supply the tumor, reducing the tumor’s ability to grow and spread.

• Progressive Fibrosing Interstitial Lung Disease (ILD): Nintedanib is effective for patients with progressive fibrosing interstitial lung disease. It helps manage symptoms and slows the progression of the disease. By limiting excess collagen buildup in the lungs, Nintedanib helps preserve lung function. This is important for patients, as it can lead to better health outcomes and improved daily living.

• Systemic Sclerosis-associated Interstitial Lung Disease (SSc-ILD): In systemic sclerosis-associated interstitial lung disease, Nintedanib helps prevent further lung damage caused by systemic sclerosis. This is a rare autoimmune disease that causes the skin and other organs to become thick and hard. It blocks pathways that promote fibrosis in lung tissue, helping manage this condition. This action stabilizes lung function and reduces the risk of serious complications.

• Other Types of Cancer: In addition to NSCLC, Nintedanib is being studied for its effectiveness in other types of cancer, including breast cancer and colorectal cancer. For instance, as of right now, it is being used with Paclitaxel to deal with Breast Cancer. Research suggests that Nintedanib may help inhibit the growth of tumors in these cancers by blocking similar receptor pathways. 

Nintedanib Side Effects

While on Nintedanib (Nindanib), you might deal with the following.

• Gastrointestinal Symptoms: You might have diarrhea, nausea, or stomach pain. Nintedanib can irritate your intestines and stomach, leading to these issues. Diarrhea can be a hassle, but diet changes or over-the-counter meds can help. Just remember to drink lots of fluids.

• Decreased Appetite: You may notice that you don’t feel hungry. This can happen because nausea and stomach discomfort make eating hard. If this keeps up, it could lead to weight loss. Pay attention to what you eat. If you’re not eating enough, ask your doctor for help.

• Elevated Liver Enzymes: Nintedanib can raise liver enzymes, which might show liver problems. This occurs because the drug can stress your liver. Regular liver tests are important. If the levels get too high, your doctor may lower your dose or change your medication.

• Weight Loss: You might lose weight. This can happen because decreased appetite and stomach issues make it hard to eat enough. If you see significant weight loss, talk to your healthcare provider.

• Cough: You may develop a cough. This can occur from irritation in your airways caused by Nintedanib. If it becomes annoying, let your doctor know.

• Upper Respiratory Tract Infection: You may be more likely to catch colds. Nintedanib can weaken your immune system, making it harder for your body to fight off infections. If you have a runny nose or sore throat, tell your healthcare provider.

• Headache: You might get headaches. These can occur due to changes in blood flow caused by the drug. If you have headaches often, discuss them with your doctor.

• Fatigue: Feeling tired is common. This can happen because nausea and not eating enough affect your energy levels. If it affects your daily life, let your healthcare team know.

• Dermal Ulcer: You may develop skin sores. This can happen from reduced blood flow or irritation due to the medication. If you see any unusual skin changes, tell your doctor.

• Urinary Tract Infection (UTI): You may get UTIs more often. Nintedanib increases the risk of infections by affecting your immune system. If you have painful urination or feel like you need to go often, get medical advice right away.

Nintedanib Price And Availability

Nintedanib price in the USA is very high. This is due to costly parts and processes. The active ingredient takes many steps to make. It uses compounds like 1-benzyl-3-ethylurea and different solvents. Careful quality checks also add to the cost.

Nintedanib price in the Philippines is lower than in the USA. Still, it remains high because of import taxes and shipping fees. Nintedanib price in Malaysia is about the same, with extra costs for getting these medicines to stores.

Nintedanib price in India is more affordable under the brand name Nindanib which is manufactured by well-known Glenmark Pharmaceutical company. If you want a better deal, you can buy Nintedanib online as generic versions at Medixo Centre. We offer the best deals with worldwide shipping so everyone has access to good healthcare. Please contact us via WhatsApp or Email now for current best price. 

Nintedanib Safety Advice

Alcohol

Nintedanib does not have a known major interaction with alcohol. However, both can lead to similar side effects like diarrhea and nausea, which may make you feel worse.

Pregnancy

Nintedanib is not safe during pregnancy. Animal studies show it can harm the fetus. It’s important to use effective birth control before, during, and for three months after treatment.

Breastfeeding

You should not breastfeed while using nintedanib. The effects on babies are not known, and the drug may build up in breast milk.

Driving

Nintedanib can have minor effects on your ability to drive. Be careful when driving or using machines because of possible side effects like dizziness or fatigue.

Liver

Nintedanib can raise liver enzymes and may harm your liver. Regular liver function tests are necessary during treatment to catch any issues early.

Doctor Advice

Talk to your doctor before treatment, especially if you have liver issues or take other meds. Regular check-ups are important to find side effects and see how well the treatment works.