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Palbociclib (Palnat) is mainly used in the treatment of hormone receptor-positive, HER 2 negative and for treating breast cancer. It works as a chemotherapeutic agent that is used along with the antineoplastic agents to treat the Hr positive advanced or metastatic breast cancer.

It is basically piperazine pyridoxamine. It works in the form of a cell cycle machine. This is a reason why it is also considered as a second generation cycle dependent kinase inhibitor. While the reason for Palbociclib being selected for the treatment of breast cancer is its favourable physical and pharmaceutical properties. It is sold under the brand name Ibrance. It works by blocking the action of the abnormal protein which gives the cancer cells the signals of multiplication. The Palbociclib in this way reduces the growth and speed of the cancer multiplication. 

Additionally, the Palbociclib is mostly used with the combinations of other medicines to enhance its effectiveness. These combinations of medicines include aromatase and fulvestrant that helps in enhancing its effectiveness. The Palbociclib when used with other medications like aromatase inhibitors help in bringing a target therapy to the harmful cells. While not affecting the healthy cells around. 

It was developed by Pfizer incorporation back in 2015. Palbociclib was originally approved by the FDA for the HR-positive, HER two negative advanced and metastatic breast cancer. So if you find someone around you who has been diagnosed with any of these diseases, then it is best to consider Palbociclib as a suitable option. 

Palbociclib Usage 

As we know that Palbociclib is a small chemotherapeutic molecular agent that can be used in treating breast cancer metastatic or in the hormone receptor positive. The working of Palbociclib is quite simple. It blocks the action that leads to the multiplication of the cells. Hence, reducing the speed and growth. 

It can be used in combination with other hormonal therapies. It can be used with different agents. The combination therapy of Palbociclib is mentioned below. 

Palbociclib combination with letrozole

Palbociclib is used in combination with letrozole. The hormone combination is considered as an initial hormonal therapy for patients. It is considered as a treatment for patients who are diagnosed with advanced HER or metastatic breast cancer.

The clinical trials also have been taken against this combination therapy and show significant results. It shows progression-free survival. While, enhancing the overall rate to 24.6%. 

Combination of Palbociclib with fulvestrant

Fulvestrant combination is used when the patient is going through major endocrine therapy. The major aim of this hormonal combination therapy is to effectively manage advanced or metastatic breast cancer refractory cases.

Absorption and bioavailability while using Palbociclib

Palbociclib has a pharmacokinetic profile test with bioavailability of almost 46%. While the plasma concentration is estimated to remain for 6 to 12 hours after the usage of Palbociclib. 

Moreover, the intake of healthy food while using the Palbociclib treatment is recommended. As it helps in the absorption process.

The metabolism and elimination of Palbociclib 

Well, Palbociclib is mainly metabolized in the liver. The main channel of its metabolism process is the cytochrome P430 3A enzyme. However, after the metabolism process, the remains of Palbociclib are eliminated through the feces. The average plasma half-time is 29 hours, which facilitates one daily usage of Palbociclib.

Palbociclib Side effects 

The side effects of using the treatment of Palbociclib can occur in many cases. These side effects are really minor and do not create problems or difficulties in the treatment. These common side effects include:

• nausea
• diarrhea
• vomiting
• decreased appetite
• changes in taste
• tiredness
• sores on the lips, mouth, or throat
• unusual hair thinning or hair loss
• dry skin
• rash
• eye tearing, blurred vision, or dry eye

There is no need to worry if you experience any of these common side effects. You can consult your doctor if you have any symptoms, but they won't get serious.

While in the other cases, there has been a history of patients ending up with some serious side effects. The major side effects include the following:

• fever, chills, or signs of infection
• difficulty breathing or shortness of breath
• cough with or without mucus
• chest pain
• dizziness
• fast, irregular, or pounding heartbeat
• weakness
• unusual bleeding or bruising
• nosebleeds
• redness, pain, swelling, or blisters on the palms of the hands or soles of the feet
• skin blistering and peeling
• skin redness

If you experience any serious side effects, it is recommended that you immediately contact your health care officials or get admitted to the hospital. The serious side effects of Palbociclib can lead to a bigger problem. 

Precautions 

There are several different ways you can avoid Palbociclib's excessive warnings. Below are the possible precautions that you can opt 

• The very first precaution is to avoid alcohol. The excessive consumption of alcohol leads to liver disease or liver damage. 
• It is always important to keep a monitor on changes in your weight. If you are losing or gaining a significant amount of weight then it is important to keep your doctor in consideration.
• You can also opt to run a regular blood test in order to check your blood count level , kidney function and the liver function to stay updated. 
• You can also regularly monitor your heart rate and blood pressure. This is another precaution that is highly effective. 

Palbociclib Price and availability 

Palbociclib is a high cost medicine that is used to treat breast cancer. However, the exact price of Palbociclib varies depending on several factors and brands. Affording the high cost of medicine is difficult, however nowadays there are several options that the patients can use in order to manage the medicine costs. These options includes; the insurance coverage, patient assistance programs or generic alternatives. 

The generic alternatives nowadays are becoming so popular due to being cost-effective solutions. These generic alternatives not only provide quality but are affordable, too. One pharmaceutical company that is bringing up the generic alternative of Palbociclib is Medixo Centre.  

Medixo Centre offers Palbociclib (Palnat) at a very affordable price with worldwide shipping. The generic alternatives of Palbociclib (Palnat) are available and distributed to more than 100 countries. The major countries where it is distributed include the Philippines, Malaysia and USA. However, as far as the Palbociclib price in the Philippines or Malaysia is concerned, it is completely dependent on the country and the generic alternatives companies. If you are looking this medicine then send your enquiry with WhatsApp or Email now. We are ready to give you our best price quotation.

Palbociclib Safety Advice

Alcohol

The patient going through the treatment of Palbociclib is recommended to avoid the excessive consumption of alcohol as it may affect liver function. 

Pregnancy

Using Palbociclib can affect the fertility level. It can harm your unborn child fetus. Hence, it is always recommended to discuss the possible contraception options with your gynecologist.

Breastfeeding

While you are using the Palbociclib treatment, it is not recommended to breastfeed the kids. As there could be the possible chance of harmful effects on your child. Thus, it is highly important to consult your doctor for the possible solution.

Driving

Palbociclib can affect your driving ability. Possible side effects include blurred vision and dizziness while driving. Thus, it is recommended to avoid driving during your medication period. 

Liver

If you are suffering from any chronic liver disease, then it is best to consult your doctor first. This will secure you from further problems, as using the palbociclib without running the tests would lead to more significant problems.

Doctor Advice

Always be aware of drug interactions. If you are taking any other medicine, it is important to always contact your doctor. Never take any medicine without the permission of your doctor. A consultant doctor can only effectively guide you about the rightful usage and effect.